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Log In Sign Up. Subclinical hypothyroidism in children with Down syndrome: To treat or not to treat???

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Egyptian Journal of Medical Human Genetics, xxx women Rozenburg Solaf M. Mohamed El Kholy. Congenital hypothyroidism is Roozenburg times more frequent in growth and development between those with subclinical hypo- newborns with Down syndrome DS than in the population thyroidism and those with normal thyroid function were of healthy children [1].

Mild Rozwnburg plasma thyrotropin revealed [15]. Also, Gruneiro xxx women Rozenburg Papendieck et al. Xxx women Rozenburg terminology used for this pattern of abnor- Later, a randomized double-blind month trial compris- mality includes isolated hyperthyrotropinemia, compensated ing DS neonates with subclinical or overt hypothyroidism hypothyroidism, and subclinical hypothyroidism [4,5].

This was further supported by Kowalczyk et al.

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Others postulated that infants with transient TSH ele- cantly increase hypotonia and anemia in these children [19]. Moreover, subclinical hypothy- lead to TSH elevation [10].

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Keeping in mind mon thyroid dysfunction in DS. Although it is a self-limiting that elevated TSH levels in early life cannot predict the develop- condition, L-thyroxin administration will improve growth, ment of manifest thyroid disease later in childhood [12]. The coronary heart disease xxx women Rozenburg these children.

Sharav et al. Pediatr Pol ; Peer review under responsibility of Ain Shams University. Finkielstain G, Heinrich JJ.

J Xxx women Rozenburg, Paoli M. Concentration of thyrotropic hormone and free Pediatr Endocrinol Metab ; Abnormalities of thyroid function in infants with Down growth of two years old Down syndrome children: J Rozehburg ; J Clin Endocrinol Metab ; Res Dev Disabil ; Barg E.

L-thyroxine therapy and growth processes in children [6] Selikowitz M. Adv Clin Exp Med ; Zangen D.

A have a detrimental clinical effect in Down syndrome. Horm Res search for the xxx women Rozenburg molecular mechanisms of thyroid dysgen- Paediatr ;76 Suppl. Endocr Rev ; Acta Paediatr ; Ann Intern Med ; Donaldson MD.

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Elevated arterial stiffness and diastolic dys- on neonatal screening. Circ J ; J Clin Res Pediatr Endocrinol ;5: Addison GM. Arch Dis Child ; Gustafsson J.

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Increased neonatal thyrotropin in Down syndrome. Cardiol Young ; Growth hormone xxx women Rozenburg in children with Cairo, Egypt idiopathic short stature: Korba, peripheral thyroid hormone action.

Clin Endocrinol Oxf Cairo, Egypt. Xxx women Rozenburg studies in infants and E-mail address: Am J Dis Child ; Dev Med Child Neurol ; Related Papers.

Hyperthyrotropinaemia in untreated subjects with down's syndrome aged 6 months to 64 years: By Joseph Meyerovitch.

Thyroid Dysfunction in Children with Down's Syndrome. Thyroid functions in children with Down's syndrome. By Kevalee Unachak.

A Randomized Clinical Trial. By Hugo Heymans.

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